PIDD: A Switch Hitter
نویسندگان
چکیده
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.
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ورودعنوان ژورنال:
- Cell
دوره 123 شماره
صفحات -
تاریخ انتشار 2005